The Gavin & Stacey star, who is hosting the music ceremony for the second year running, admitted that he can only fulfil his duties through a series of injections.
Speaking to Xfm, Corden explained: "My knee is killing me. I'm waiting for an operation.
"But there's nothing I can do until I've finished my run of One Man, Two Guvnors at The Strand."
The 33-year-old added: "I've been getting injections and I'll have to make sure I don't do any more damage on the night."
The BAFTA-winning comic writer and performer is waiting to undergo surgery on damaged cartilage in his right knee
Before hosting the 2011 Brits, Corden suffered a scratched cornea, leaving him with blurred vision as he took to the stage.
> James Corden: 'Blur to play for record time at Brits 2012'
