The rapper and dubstep duo are joined by Nero, Friendly Fires, Maverick Sabre, Labrinth and Wretch 32 at the event, which will take place between June 14-18.
DJ Fresh, Ben Howard, Ghostpoet, Toddla T and Clement Marfo & The Frontline will also play the four-day festival at Pembrey Country Park in Wales.
Tickets for Beach Break Live are on sale now and start at £109, with festival-goers able to book their place with a £40 deposit.
Last year's event saw performances from Tinie Tempah, Professor Green, Katy B, White Lies and Ed Sheeran.
Watch the official promo for Beach Break 2012 below: