The singer-songwriter claimed that she is "disappointed" with the current music scene and questioned whether LMFAO were "a joke band".
Asked about allegations on whether her recent buzz track 'Big Mouth' was an attack on Lady GaGa, Santigold told Pitchfork: "I'm disappointed with the state of music right now, but it's not really about anybody specific.
"I think there's a lack of true art, and the fanfare is valued over actual substance. It's like you don't have to make good music to be f**king huge."
She added: "I'm sorry, but LMFAO performed at the Super Bowl? Aren't they a joke band? That type of s**t makes me cry. I'm like, 'Really?'"
However, the star did reveal that she is a fan of Adele and Beyoncé, before explaining the themes behind her new album Master Of My Make-Believe.
Santigold continued: "Most of the songs are about being in control of your world. That was a really important message for me as an artist in this process, but also in the world right now.
"We're in a weird place. There are so many riots and rebellions going on. It seems like a truth is coming out."
Santigold's Master Of My Make-Believe is expected to be released on April 23.
Listen to Santigold's new single 'Disparate Youth' below: