Cornell and Chesney will perform in Austin, TX on April 20 at 'We Walk the Line: A Celebration of the Music of Johnny Cash', which is being organised in remembrance of what would have been Cash's 80th birthday.
Ray LaMontagne, Amy Lee, Carolina Chocolate Drops and Jamey Johnson are also on the bill for the Austin City Limits Live gig.
Country music legend Kris Kristofferson, Lucinda Williams and Shooter Jennings will perform as well.
Tickets for the event go on sale today (February 29)
'We Walk the Line: A Celebration of the Music of Johnny Cash' is the latest in a series of tributes to the 'Hurt' singer, who died in 2003 at age 71.
Collections of Cash's final recordings have been released in recent years and earlier this month ground was broken on a museum celebrating the star's life and influence.
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Watch Johnny Cash perform 'Walk The Line' below: