The boyband will perform their debut US single 'What Makes You Beautiful' at the awards ceremony, which is being held at the Galen Centre in LA later this month.
One Direction's appearance on the Kids' Choice Awards marks the beginning of a partnership with Nickelodeon, which also sees them host the network's weekend programming throughout March and appear on iCarly.
Will Smith, who holds the all-time winning record at the Kids' Choice Awards, will serve as the host for this year's ceremony.
Miranda Cosgrove, Selena Gomez, Tim Allen and Ty Burrell are among this year's television acting nominees, while American Idol, iCarly and Kung Fu Panda are nominated in the various television categories.
Jim Carrey is nominated against Johnny Depp, Adam Sandler and Harry Potter star Daniel Radcliffe for 'Favourite Movie Actor'. Kristen Stewart is competing in the 'Favourite Movie Actress' category with Amy Adams, Sofia Vergara and Emma Watson.
Lady GaGa, Justin Bieber, Katy Perry and Taylor Swift are among the music nominees.
Nickelodeon's 25th Annual Kids' Choice Awards airs Saturday, March 31 at 8/7c.
> Nickelodeon Kids Choice Awards 2012: Nominations in full
Watch One Direction's 'What Makes You Beautiful' music video below: