The DJ has teamed up with US singer Ne-Yo for 'Let's Go', which is to be the third track lifted from his forthcoming album.
'Let's Go' follows Harris's previous cuts 'Bounce' and 'Feel So Close', which both reached number two on the UK singles chart last year.
Along with working on his own record, Harris is rumoured to have teamed up with Leona Lewis for new song 'You've Messed Up' and has worked with Cheryl Cole on her upcoming album.
Harris has also written a track for a new Pepsi campaign, which is backed by footballers including Fernando Torres, Frank Lampard and Didier Drogba.
The producer's as-yet-untitled third studio album is expected to be released later this year.
> Calvin Harris named UK's most successful songwriter of 2011
Listen to Calvin Harris and Ne-Yo's 'Let's Go' below: