The 2012 music event at Henham Park, Suffolk will take place on the weekend of July 12-15.
The Horrors, Laura Marling, Wild Beasts and White Lies are among the 60-plus acts that have been confirmed so far.
Professor Brian Cox will present BBC Radio 4's science programme The Infinite Monkey Cage during the event, while classical pianist Lang Lang will make his outdoor festival debut.
Jack Dee, Tim Minchin and Reginald D Hunter are among the comedy performers, while Daryl Hall of Hall & Oates, Thomas Dolby and Buena Vista Social Club will also appear.
Michael Kiwanuka, Simple Minds, Bat for Lashes, M83, Lloyd Cole and Metronomy are also among the long list of notable acts.
Paul Weller and Elbow will also headline two shows at the Jodrell Bank observatory in June.
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The full list of confirmed acts so far is as follows:
Amandou & Mariam
Bat For Lashes
Buena Vista Social Club
Edward Sharpe and the Magnetic Zeroes
Explosions In The Sky
Francois and the Atlas Mountains
I Break Horses
Josh T Pearson
Lianne La Havas
Sharon van Etten
Sissy & The Blisters
The War on Drugs
We Have Band
Zun Zun Egui