The 'Part of Me' singer will take the stage to perform the single at the March 31 ceremony, held at the University of Southern California (USC)'s Galen Centre in Los Angeles.
"Katy Perry has doubly earned her position as kid favourite - through her music, of course - but also for revelling in an outrageous sliming on the show two years ago," said president of Original Programming and Development at Nickelodeon Marjorie Cohn in a statement.
"She works hard and plays hard, and that's what makes her performance on the KCAs one to look forward to."
Perry, who was recently announced as the guest performer on this weekend's Let's Dance for Sport Relief grand final in the UK, has been nominated in the 'Favourite Song' category for her track 'Firework'.
She also received nods in 'Favourite Female Singer' and 'Favourite Voice in an Animated Movie' categories for her role in The Smurfs.
The 25th annual Nickelodeon Kids' Choice Awards will be hosted by Will Smith and will also include a performance by boyband One Direction.
Listen to Katy Perry's 'Part of Me' below: