The singer, who has collaborated with Brown for her new album All Of Me, insisted that people are being harsh on the star, who was convicted of assaulting then-girlfriend Rihanna in 2009.
She told Vibe: "I feel like Chris is an incredible singer, musician, dancer, entertainer, and brain box as far as business and that's why I respect him and that's where we meet at because I have nothing else to go on.
"I get it, I understand, and I get the effects for young women. I can't speak on it because I wasn't there. Parents, raise your kids. Young men and women, raise your kids. Don't let us raise your children. That's my take on it."
Estelle added: "I respect him, I love him, he does amazing music, and has evolved. He's worked his ass off, so why are people still crucifying him?"
On his treatment by the media, she said: "I just think people need to worry about their lives per say. Don't worry about who he's recording songs [with], who he's doing this with if you enjoy the music.
"We all make mistakes. A sin is a sin is a sin. It's no big smoke, let the boy live. He does music."
Estelle recently addressed rumours that she will be a judge on the next series of The X Factor, saying: "I would absolutely do it."
> Estelle: 'British R&B stars have it f**king hard'
Watch Digital Spy's recent interview with Estelle below: