The band will include their first 14 singles on Souvenir, which will be released on June 4 and contain two brand new tracks.
New cuts 'On The Run' and 'Listen To Your Head' will feature alongside their most popular tunes including 'Ruby', 'I Predict A Riot' and 'Oh My God'.
"People get blinded by our stripy blazers, but we're more political than most bands," frontman Ricky Wilson told the Daily Star.
"Our biggest hits are actually pretty gloomy. Even 'Ruby', the one song we've written about love, says the best bit of a relationship is the time between first seeing someone and finding out their name."
However, Wilson insisted that the band releasing a retrospective of their career to date does not mean they are about to split.
He added: "This isn't the end but even I was surprised when I looked at the stats to see what we've achieved. We've amassed enough singles to put out a more-than-solid compilation."
Kaiser Chiefs will play this year's Reading and Leeds Festivals between August 24-26.
> Kaiser Chiefs: 'We crave mainstream success'
Watch the music video for 'I Predict A Riot' by Kaiser Chiefs below: