The singer will officially premiere new cut 'Dance Again' in full on March 30, while the accompanying music video will follow on April 5.
The song will feature Pitbull. He previously collaborated with Lopez on her worldwide smash 'On The Floor', which topped the US and UK charts last year.
It is not yet known whether 'Dance Again' will head a new studio album from Lopez or serve as a new single to be included on a greatest hits compilation.
Vocal producer Kuk Harrell has previously said that he will be working with Lopez on a greatest hits release and revealed that Tricky Stewart and The-Dream have been booked to work on the project.
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Listen to a clip of Jennifer Lopez's 'Dance Again' below: