The 'Read All About It' star explained that he will "punch in the face" those who challenge him for a contest.
When asked by Q if anyone could take him on in a rap battle, he replied: "Not unless they wanted a punch in the face."
He added: "If they asked politely, I'd politely tell them to f**k off. Every time I do a radio or TV interview, they're like, 'You used to freestyle - so go on then'. I'm not a monkey with a box full of 50 pence pieces.
"If you saw Nigel Mansell you wouldn't say, 'Give us a quick lap'. It's a bit of a wind-up."
Professor Green recently confirmed that he will work with Slipknot on a new track.
He will be one of the supporting acts for the upcoming reunion tour of The Stone Roses at Heaton Park on June 30.
The rapper recently stated that he hated performing his debut single 'I Need You Tonight'.
> Professor Green: 'I'm careful after my dad's suicide'
Watch the video for Professor Green's 'Read All About It' below: