The Swedish hardcore band were due to play Sonisphere until the gig was cancelled last Thursday.
Group member Dennis Lyxzén is quoted by NME as saying: "We're very excited to have been given the chance by the people at Download to play the festival and meet our UK fans for the first time in 15 or so years."
Download will be the only UK festival appearance this summer for Refused, who reformed in January after 12 years apart.
Taking place at Donington Park between June 8 and 10, the annual jaunt will be headlined by The Prodigy, Black Sabbath and Metallica.
Meanwhile, the likes of Queen, Adam Lambert, Kiss and Faith No More had been due to play at Sonisphere.
Watch Refused perform 'New Noise' below: