The guitarist quit Guns N' Roses in October 1996 and has not reconciled with the frontman since.
"He hates my guts," Slash told Rolling Stone. "It's over a lot of different stuff; I don't even know.
"There's just no communication between us. I talk to [bassist] Duff [McKagan] and [drummer] Steven [Adler], but when it comes to old Guns N' Roses, there really isn't anybody that makes decisions."
Slash again said that the Appetite For Destruction lineup would not perform together at their Rock and Roll Hall of Fame induction on April 14.
"This is a subject I'm dead-sick of talking about," he explained.
"Everyone has been asking me what's going to happen, and they know as much as I do.
"I feel you're totally obligated to be present and I would love to f**king play, but it's just something that's not gonna happen for whatever reason."
Rose has previously hinted that he would be open to reuniting with Slash and McKagan, but would prefer to keep his current Guns N' Roses colleagues rather than reintroduce Adler or guitarist Izzy Stradlin
Keyboard player Dizzy Reed previously confirmed that he, Slash, Rose, McKagan, Adler and Stradlin would attend the induction ceremony.
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Watch the Guns N' Roses 'Welcome To The Jungle' music video below: