The group will debut 'Only The Horses' on Friday, April 6 on BBC Radio 1.
They tweeted: "Scissters, this Friday will be a Good Friday indeed, as we are thrilled to exclusively world premiere our brand new single #OnlyTheHorses! (sic)"
They added: "..it will be played for the FIRST TIME ANYWHERE by @FearneCotton on @BBCR1 this Friday, 6th April.
"Tune in between 10am-12.45pm UK time to listen on FM or online worldwide. We're jazzed to be able to share it with you."
The track, which was co-produced by Calvin Harris and Alex Ridha (Snoop Dogg, Depeche Mode), trails their fourth studio album Magic Hour on May 28.
The band recently announced that they have worked with Pharrell Williams and Diplo on the LP, adding: "Magic Hour is a sweet joyful melange of beat-driven future-pop. It style-hops all over the place unabashedly."
Watch the video for Scissor Sisters' recent track 'Shady Love' below: