The singer was asked by The Guardian whether he thought the band would play live again after the Hyde Park concert on August 12, which will mark the end of the 2012 Olympics.
Albarn responded: "No, not really."
When pushed to confirm whether he meant that was it for Blur, he said: "I think so, yeah.
"And I hope that's the truth: that that's how we end it. I don't know - you can write scripts, and they always end up going… well, one thing I've learned, and I'm sure you're exactly the same, is that everything I think I've got totally sorted out, and I know exactly what's going to happen - it never works out that way…"
Albarn also suggested that the band's recording days are numbered, hinting at behind-the-scenes difficulties.
Asked whether there would be any more Blur records, he replied: "No, I don't think so.
"I find it very easy to record with Graham [Coxon]. He's a daily musician. With the other two, it's harder for them to reconnect. You know what I mean? It's fine when we play live - it's really magical still - but actually recording new stuff, and swapping musical influences… it's quite difficult."
Albarn later confirmed that this would "in all likelihood" be the end of Blur.
The band will be joined by The Specials and New Order for their Hyde Park gig on August 12.
Albarn recently unveiled 'The Marvelous Dream', the first single from his upcoming solo LP.
Watch Blur perform new track 'Under The Westway' below: