Speaking to The Guardian, the Blur frontman revealed that he and Hewlett had fallen out while making latest LP The Fall.
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"I think we were at cross purposes somewhat on that last record, which is a shame," he said.
When pressed on whether he is no longer on friendly terms with Hewlett, Albarn admitted: "That sounds very juvenile, doesn't it? But being juvenile about it, it happens. It's a shame."
The 44-year-old singer-songwriter added that a reunion is "unlikely" unless "a time comes when that knot has been untied".
Formed in 1998, Gorillaz have released three platinum-selling albums, peaking with 2005's Demon Days.
The supergroup recently teamed up with James Murphy and Andre 3000 for 'DoYaThing'.
> Damon Albarn thinks Hyde Park will be Blur's last
Watch the music video for Gorillaz's 'DoYaThing' below:
