The singer-songwriter will play ten shows across the UK in November and December.
Wainwright will be performing with a new eight-piece band, which includes Teddy Thompson on guitar and Krystle Warren on backing vocals.
He will kick off the tour at Oxford's New Theatre on November 16, before finishing at Glasgow's O2 Academy on December 14.
Tickets go on sale on April 20.
Wainwright will release his upcoming seventh studio album Out of the Game on April 23.
The Mark Ronson-produced LP has been described by the singer as his "most pop" record to date.
The American-Canadian performer will first release new single 'Out of the Game' on April 16. The song's video features actress Helena Bonham Carter.
Rufus Wainwright's tour dates are as follows:
- November 16 - Oxford, New Theatre
- November 17 - Birmingham Symphony Hall
- November 18 - London, Hammersmith Apollo
- November 20 - Nottingham, Royal Concert Hall
- November 21 - York, Barbican
- November 23 - Bristol, Colston Hall
- November 24 - Brighton, Dome
- December 11 - Manchester, O2 Apollo
- December 13 - Edinburgh, Usher Hall
- December 14 - Glasgow, O2 Academy