The singer-songwriter's appearance will mark the passing of the Live Music Act, which aims to help small venues put on music events in the UK.
The act, which was passed last month, will allow venues with a capacity of under 200 to stage gigs without the need to apply for a license.
The event is hosted by industry body UK Music, and will also see performances by Daytona Lights and MP4, a band consisting of politicians.
Suede's Bernard Butler and Robert Wyatt are set to be in attendance to celebrate the passing of the bill, reports NME.
Topley-Bird released her fourth studio album Some Place Simple in 2010.
She also collaborated with Massive Attack on their 2010 LP Heligoland.
Watch the video for Martina Topley-Bird's 'Carnies' below: