The London duo will play the Eden Project venue in Cornwall on July 4, with Labrinth as their support act. They previously headlined a sell-out Eden Project gig in May 2010.
Chase & Status are currently working on their as-yet-untitled third studio album, which is due for release later this year.
Other acts confirmed for this year's Eden Sessions include Blink-182 (July 8), Plan B (July 6), The Vaccines and Noah and the Whale (both July 11).
For ticket information, visit the Eden Project website.
The lineup for this year's Eden Sessions so far is as follows:
Tim Minchin (June 23)
Example, Devlin (June 30)
Frank Turner, Bellowhead, Mull Historical Society (July 1)
Chase and Status, Labrinth (July 4)
Plan B (July 6)
Blink-182 (July 8)
Noah And The Whale, The Vaccines (July 11)
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Watch the music video for Chase and Status's 'Let You Go' below: