The Canadian songstress continued to dominate the Top 40, fighting off challenges from Conor Maynard, John Legend and B.o.B. to stay top for another week.
Maynard debuted at number two in the Official Singles Chart with his single 'Can't Say No', making the 19-year-old this week's highest new entry.
John Legend, who returned to the charts with 'Ordinary People' last week thanks to a performance by Jaz Ellington on The Voice, saw his single jump from number 27 to number four - its highest ever chart position.
Another top climber came from Jessie J ft. David Guetta, as their track 'LaserLight' shot up 21 places to number five.
B.o.B., meanwhile, entered the chart at number seven with his latest track 'So Good'.
As Jepsen continued to fly high in the chart, the teenager's label boss Justin Bieber fell from number two to number ten with his latest release 'Boyfriend'.
Nicki Minaj, Gotye and Sean Paul all continue to hold on in the top ten, each falling three places.
Elsewhere in the chart, Linkin Park return with 'Burn It Down' at number 27, and San Francisco band Train entered the Top 40 at number 14 with 'Drive'.
Watch the video for Carly Rae Jepsen's 'Call Me Maybe' below:
Source: Official Charts Company
> This week's album chart