The band, who reformed in 2009 after previously splitting in 2001, play the O2 Academy Brixton on December 1.
Tickets are available now and are priced at £25.
"It's been very natural and unforced - a bit like coming home," said frontwoman Skin of the reunion.
"We have a huge fan base that was screaming out for us to do something. We got back together because we have a strong chemistry."
She added: "We're very proud of our past work, but what drives us is the future."
Skunk Anansie's 2010 comeback album Wonderlustre followed a previous greatest hits compilation Smashes And Trashes.
Watch the Skunk Anansie 'Weak' music video below.