The teenage popstar will screen the full promotional clip and also take part in a one-on-one interview with MTV's Sway, the network announced today (May 1).
The chat will also feature Sway asking questions sent in by Bieber's fans on Twitter.
MTV First: Justin Bieber will premiere 'Boyfriend' at 7.50/6.50pm EST on Thursday evening on television, followed by the interview with Sway exclusively on MTV's official website.
'Boyfriend' is the lead single from Bieber's upcoming third studio album Believe, which is released on June 18 in the UK and June 19 in the US.
Bieber was spotted earlier this week working in a studio with Kanye West, who is apparently putting the "finishing touches" to Believe.
Listen to Justin Bieber's hit 'Boyfriend' below: