Directed by Lopez's boyfriend Casper Smart, the video is set in Acapulco, Mexico, and showcases the 42-year-old mother of two's impressive body.
Lopez sports a number of fake tattoos, including a large one that covers her back and is reminiscent of Lisbeth Salander's ink in The Girl with the Dragon Tattoo, as well as one across the chest that reads "leader" in Spanish.
The video starts with Lopez on a rooftop before she goes on the run as she is pursued by her friends through the city.
The singer is reportedly ready to marry Smart. She parted ways with ex-husband Marc Antony in July of last year.
Lopez recently said that she may adopt a child in the future, revealing that her work on What to Expect When You're Expecting has inspired her to consider the process.
Watch the video for 'Follow the Leader' below: