The 'Godfather of go-go' passed away at Baltimore's Johns Hopkins Hospital yesterday (May 16) after reportedly suffering multiple organ failure due to sepsis.
He had recently cancelled a number of live shows after being hospitalised for pneumonia.
"Go-go is DC's very own unique contribution to the world of pop music," said mayor of Washington DC Vincent Gray in a statement.
"Chuck Brown was regarded as go-go's creator and, arguably, its most legendary artist."
He added: "Today is a very sad day for music lovers the world over, but especially in the District of Columbia.
"Without Chuck Brown, the world - and our city - will be a different place. What a loss."
Brown started his music career in the 1960s and his first album was 1972's We The People as a member of The Soul Searchers. He continued to play live until shortly before his death.
Watch ABC7's news report on the passing of Chuck Brown below: