The 'No One' singer is set to present the Icon Award to Stevie Wonder. The pair will also perform on stage together.
Wonder will be recognised for his legendary career in the music industry that has spanned for more than 30 years.
Other presenters expected at the awards show include Zooey Deschanel, Robin Thicke, Miley Cyrus, Lisa Marie Presley, Whoopi Goldberg, Charlie Sheen and Brandy.
Carrie Underwood, whose new album Blown Away debuted at number one in the Billboard Music charts, will perform. Other performers include Usher, Justin Bieber, Nelly Furtado, John Legend and Kelly Clarkson.
Hosted by Modern's Family Julie Bowen and Ty Burrell, the 2012 Billboard Music Awards will air live on Sunday, May 20 at 8pm-11pm ET on ABC.
Watch the music video for Alicia Keys's 'No One' below: