The two-day event is curated by Jay-Z, who will also perform at the festival which takes place at Philadelphia's Fairmount Park on September 1 and 2.
Odd Future, Skrillex, Santigold, Janelle Monae, Rita Ora, Calvin Harris, Miike Snow, Passion Pit and Dirty Projectors are also on the lineup.
R&B singer D'Angelo is set to make his comeback at the event.
Jay-Z first announced the Labour Day weekend event earlier this month.
The rapper has stated that he "absolutely" intends to ask US President Barack Obama to appear at the festival.
Tickets for the event go on general sale to the public today (May 23).