The Garbage frontwoman stopped singing 'Stupid Girl' when she saw a man hit a woman in the crowd at the sold out House of Blues show.
According to WENN, Manson yelled: "Get the f**k off her right now... Dude, never hit a f**king woman. What the f**k is wrong with you, man?"
Manson then told the male fan to leave the concert, saying: "You've got to leave, man. You can't f**king fight, man... It's the rules, man."
After the man was removed, Manson attempted to calm showgoers.
She added: "I just think we all just need to simmer down... I think there's some bad karma in this room."
Garbage are currently on tour promoting their latest album Not Your Kind of People.
Watch Garbage's 'Blood for Poppies' video below: