The former X Factor star will play the Camden Roundhouse on September 3 as part of the month-long series of concerts.
"I am going to bring my live nine-piece band and hope that I too can put on a great show," Murs told Metro.
"I went to see Chase & Status last year for their iTunes Festival gig and it was a brilliant atmosphere."
He added: "It's an amazing event to be part of and one that I have always wanted to play."
Murs is joined on the 2012 bill by other X Factor alumni Rebecca Ferguson and One Direction.
Other acts already confirmed for this year's iTunes Festival include Usher, Emeli Sandé, Jack White and Noel Gallagher's High Flying Birds.
Tickets will be available for free for competition winners, and can be applied for on the festival website.