The 'Take Care' singer has teamed up with rapper 2 Chainz on the track, for which a music video was just released.
A verse in the song has now been deemed by some as a thinly-veiled insult to Rihanna, according to The Huffington Post.
In the verse Drake raps: "Aww that look like what's her name, chances are it's whats her name/Chances are if she was actin up, then I f**ked her once and never f**ked again/She could have a Grammy, I still treat her ass like a nominee/Just need to know what that p***y like so one time is fine with me."
The single release comes just days after a reported club brawl between Drake and singer Chris Brown, allegedly sparked by an argument over the five time Grammy-winning 'Birthday Cake' singer.
An investigation into the incident is ongoing, though neither Drake nor Brown have confirmed whether or not Rihanna was the catalyst for the incident.
Watch Drake in the video for 'No Lie' below: