The rapper's latest hit 'Whistle' remains at number one and prevents will.i.am's 'This Is Love' from hitting the top spot.
The Black Eyed Peas star's latest single enters at number two, while Cheryl Cole slips to three with 'Call My Name'.
Maroon 5 are at four with 'Payphone', Loreen is at five with 'Euphoria' and Katy Perry's 'Wide Awake' moves up to eight.
Chris Brown advances four places to 14 with 'Don't Wake Me Up', Stooshe are at 18 with 'Black Heart' and Nicki Minaj follows at 19 with 'Pound The Alarm'.
Usher's 'Scream' is at 26, Labrinth's 'Express Yourself' is at 29 and Emeli Sandé's 'My Kind Of Love' is at 35.
This week's Irish Top 10 is as follows:
1. (1) Flo Rida: 'Whistle'
2. (-) will.i.am ft. Eva Simmons: 'This Is Love'
3. (2) Cheryl: 'Call My Name'
4. (3) Maroon 5 featuring Wiz Khalifa: 'Payphone'
5. (4) Loreen: 'Euphoria'
6. (6) fun. featuring Janelle Monaé: 'We Are Young'
7. (5) Coldplay and Rihanna: 'Princess Of China'
8. (12) Katy Perry: 'Wide Awake'
9. (8) Train: 'Drive By'
10. (7) Marina and the Diamonds: 'Primadonna'
Watch the music video for Flo Rida's 'Whistle' below: