The quartet performed classic tracks including 'I Wanna Be Adored', 'Mersey Paradise' and 'Sally Cinnamon' in front of a crowd of over 70,000 people, with frontman Ian Brown telling fans: "Yeah, as you see we still got it."
The band announced that they were reforming last year following a bitter split in 1996. Last night's homecoming concert was their first large-scale show in the UK since the fall-out.
It marked the start of a three-night stint topping the bill at Heaton Park, which will be followed by a series of festival dates later in the summer.
Brown had previously insisted that he would need to be begging on the streets before he would consider a Stone Roses reunion.
The group revealed that it was the funeral of Gary "Mani" Mountfield's mum last April that eventually brought them back together.
In preparation for the Manchester dates, they performed a secret gig at Warrington's Parr Hall in May. They have also played some small European festival dates.
Tickets for the remaining shows this weekend are so sought-after that they have been selling for thousands of pounds, reports Sky News.
Photo gallery - Stone Roses comeback gig: