The DJ has teamed up with Chris Brown and Lil Wayne for 'I Can Only Imagine', which is the sixth single to be lifted from his latest album Nothing But The Beat.
The accompanying music video sees Guetta and Brown performing in an electronic matrix, while Lil Wayne hangs out at a virtual skate park.
Guetta recently told Digital Spy that he is already working on his next mainstream release and hopes to work with singer-songwriter Sia again.
Asked if he'd work with the star again in the future, the French producer replied: "Yes, she's amazing! Definitely, 100%. We worked together on 'Wild Ones', you know, and also we've been playing other records together and she's just incredible."
'I Can Only Imagine' is available to download now.
Watch the music video for David Guetta, Chris Brown and Lil Wayne's 'I Can Only Imagine' below: