The duo will release 'Winner' on July 3 as the trailer cut from their upcoming album Elysium.
A physical CD and 12" edition as well as a digital bundle of the single, which will contain three extra tracks, will follow on August 6.
Neil Tennant and Chris Lowe recorded Elysium earlier this year in Los Angeles with US producer Andrew Dawson (Kanye West). The collection features 12 new songs.
"It was inspiring to make an album in Los Angeles, and to work with a producer from a different musical genre, who has brought a new dimension to our music," the band stated.
Elysium will be released in the UK on September 17.
> Pet Shop Boys debut new track 'Invisible' - listen
Listen to Pet Shop Boys' new single 'Winner' below: