The track will be the first to be lifted from their fourth studio album Battle Born.
© Island Records
'Runaways' will receive its radio premiere on Tuesday, July 10, while the album will be released in the autumn.
Explaining the album's title, Brandon Flowers recently said: "In a sense, all Americans are battle born. Our ancestors came here for something better."
The Killers will make their live comeback at the V Festival in August.
Watch the Battle Born album trailer below:
