The track will be the first to be lifted from their fourth studio album Battle Born.
'Runaways' will receive its radio premiere on Tuesday, July 10, while the album will be released in the autumn.
Explaining the album's title, Brandon Flowers recently said: "In a sense, all Americans are battle born. Our ancestors came here for something better."
The Killers will make their live comeback at the V Festival in August.
Watch the Battle Born album trailer below: