The Harmony Korine-directed movie stars James Franco, Selena Gomez, Vanessa Hudgens and Ashley Benson.
> James Franco: 'Selena Gomez, Vanessa Hudgens hungry for indie films'
The plot focuses on a group of college girls who become involved with a drug and arms dealer after robbing a restaurant to fund their spring break trip.
"I think this film is going to turn a lot of heads in many ways. It was a lot of fun to work with Harmony because he gave me the freedom and trust to do whatever I wanted," Skrillex said, according to Rolling Stone.
"Scoring to film is definitely a different approach to music making in the sense that it's not so much about how the music sounds by itself as it is finding ways to complement the vibe of the film."
Spring Breakers is due to be released in 2013.
Gomez recently described the indie project as "completely different" to any of her previous roles.