The metal giants will team up for a four-stop jaunt across the nation in November.
The mini-tour will kick off at a still-to-be-confirmed London venue on November 26, followed by performances at Manchester Arena on November 27, Glasgow SECC on November 28 and Birmingham's National Indoor Arena on November 29.
Manson will embark on the tour in support of his latest album Born Villain, released back in May.
Rob Zombie is currently working on his fifth studio album, the follow-up to 2010's Hellbilly Deluxe 2.
The pair will perform at:
London TBC (November 26)
Manchester Arena (27)
Glasgow SECC (28)
Birmingham NIA (29)
Watch Marilyn Manson talk to Digital Spy about his latest album below: