The singer's latest single 'Spectrum' continues to top the midweek chart, after it became Florence + the Machine's first ever UK number one single on Sunday.
However, Maroon 5's 'Payphone' is only 700 copies behind at number two, while Stooshe's 'Black Heart' reaches a new peak at three.
will.i.am is at four with 'This Is Love' and Chris Brown is at five with 'Don't Wake Me Up'.
X Factor 2011 contestant Misha B lands at number nine with her debut single 'Home Run', while B.o.B. and Taylor Swift's 'Both Of Us' debuts at 26.
Elsewhere, Kylie Minogue's 'Timebomb' vaults up 118 places to a new peak of 29 after a limited run of physical singles were released.
Over on the album chart, Pnau's re-imagining of Elton John's back catalogue is on course to claim the Aussie duo their first ever UK number one album.
Maroon 5 are at three with Overexposed, Nas enters at four with Life Is Good and Ed Sheeran is at five with +.
The original cast recording of Lord Andrew Lloyd Webber's Jesus Christ Superstar is at 22, while Hans Zimmer's Batman soundtrack for The Dark Knight Rises is at 34.
Watch the music video for Florence + the Machine's 'Spectrum' below: