The Californians have teamed up with Aloft Hotels for the 'Play & Stay at Aloft' contest, which will give one group the opportunity to write and record a track with them.
Hopefuls must first submit a demo to email@example.com.
Finalists will be selected and given the chance to perform at one of three Aloft hotels worldwide. We Are Scientists will judge the acts and choose which one to work with.
After a 12-hour writing and recording session, the winning band will play their track live with We Are Scientists at an exclusive gig on November 1.
"We're looking forward to spending 12 hours locked away with the winning band at Aloft London Excel creating what is destined to be something pretty incredible," said the band's Keith Murray.
The recording session will also be streamed live by Aloft on Facebook, allowing fans to interact with the bands and get a glimpse into the creative process.
We Are Scientists first broke into the public eye with their 2006 album With Love and Squalor. They are currently recording a new album, due out in early 2013.