The track is the second to be taken from the group's latest album In Our Heads, and the band have also unveiled a music video for the song.
The video is directed by Rollo Jackson and was shot in London and LA.
'How Do You Do?' is released on September 10 and its 12" package features remixes from Todd Terje, Ossie, Mickey Moonlight and James Zabiela.
Meanwhile, Hot Chip have recorded the introductory music for table tennis at this year's London 2012 Olympics.
The group play a full UK tour this October following a series of festival shows over the summer, including sets at Camp Bestival, Electric Picnic and Bestival.