The singer will play the intimate show at the island's legendary Es Vive as part of the Sony Entertainment Network Ibiza, a series of music, film and gaming events taking place on the White Isle in August.
Santigold said: "I'm really looking forward to the gig and playing the new album to Ibiza for the first time.
"I've never been there before. I've heard it's a real dance-party capital, so I'm interested to see it all in action. I'm excited to bring something fresh to the island."
The star will perform tracks from her latest album Master of my Make-Believe as well as songs from her debut Santogold to an audience of just 250 in the prestigious venue.
Sony is offering fans a chance to win three nights at a luxury Ibiza hotel with €1,000 spending money at sonyentertainmentnetwork.com/ibiza, where they are asking fans to upload an image that entertains them most.
Watch the music video for Santigold's latest track 'The Keepers' below: