Delilah, Aiden Grimshaw, Devlin and Niki and The Dove will join the music event's bill, which takes place at Hylands Park, Chelmsford and Weston Park, Staffordshire on August 18-19.
Josh Osho, Gabrielle Aplin, Dot Rotten, Marlon Roudette and Lonsdale Boys Club will also perform sets ahead of headliners The Killers and The Stone Roses.
However, LMFAO have had to pull out of the two-day event citing illness as the reason for their cancellation.
Nicki Minaj, Cher Lloyd, Frank Ocean, Olly Murs, Noel Gallagher's High Flying Birds and Happy Mondays are among the acts previously confirmed for V Festival 2012.
Watch the music video for Conor Maynard's latest single 'Vegas Girl' below: