The electronic artist has titled his new LP > album title goes here <, with a release date of September 24.
Imogen Heap, My Chemical Romance's Gerard Way and Cypress Hill will feature on his sixth studio album.
Lead single 'Professional Griefers' features Way on vocals and will be released on August 24.
The announcement comes just days after Deadmau5 had hinted he was going to take a break from working.
Deadmau5 is scheduled to perform at London's Roundhouse on September 9 as part of this year's iTunes Festival.
The tracklisting is as follows:
'There Might Be Coffee'
'Take Care Of The Proper Paperwork'
Listen to 'Professional Griefers' below: