The 'Welcome to the Jungle' band will take up a residency at The Joint in the Hard Rock Hotel & Casino on Halloween (October 31).
Guns N' Roses will play 12 concerts in all, wrapping up just before Thanksgiving on November 24.
The current incarnation of Guns N' Roses features just singer Axl Rose from the original line-up.
Guns N' Roses' classic incarnation was inducted into the Rock and Roll Hall of Fame this year, but Rose pulled out of attending at the last minute.
Rose later explained that he dropped out of the induction ceremony because he doesn't understand the function of the Hall of Fame.
"I still don't exactly know or understand what the Hall is or how or why it makes money, where the money goes, who chooses the voters and why anyone or this board decides who, out of all the artists in the world that have contributed to this genre, officially 'rock' enough to be in the Hall," Rose wrote in a letter to fans.
It was also reported earlier in the year that a Guns N' Roses biopic is currently in the works.
Watch Guns N' Roses' 'Live and Let Die' music video below: