The band will perform a headline set at The Forum in Kentish Town on September 10 in support of their upcoming album Battle Born.
The Killers announced the gig on Zane Lowe's Radio 1 show last night (August 14) and revealed that the set will be broadcast live on the station.
Fans can register for tickets by entering a ballot between August 28 and September 1 through BBC Radio 1's official homepage.
The Killers will release 'Runaways' as their new single on September 9, while Battle Born will follow on September 17.
Watch the music video for The Killers' 'Runaways' below: