The rapper pulled out of her scheduled performances at the weekend, citing "vocal cord issues" as the reason.
She has since cancelled Tuesday's gig at Dublin's Olympia Theatre, but took exception to fans airing their disappointment on Twitter.
"I am so thankful to my true fans who understand WHY I couldn't play #VFestival & WHY I can't play Dublin. Absolutely gutted," Minaj tweeted.
"However, if u have anything negative to say to me, please #EatS**tAndDie - I am human. I was in jeopardy of losing my voice entirely and needing surgery on my vocal chord. If u can't understand that, your mother's a WH*RE!
"I will NOT let you people make me feel horrible for a f**king HEALTH issue! That's what got me in this mess! I shldve listened 2 the doctor! Like people are hitting me telling me I shldve mimed. No! Then you woulda made a f**king STORY out of that too! #killyaf**kingself.
"My beloved United Kingdom, u know how much I f**king love u! Ireland, I truly appreciate you. Barbz, thnku for the well wishes."
She added: "All you do is rip people apart and when they're dead & gone u won't lose a wink of sleep. #goF**kYourselves. Barbz, u know how much I hate disappointing u guys."
Minaj was recently accused of failing to show up at an after-show party for which she'd been paid $30,000 (£18,700) to appear at.
Watch Nicki Minaj's video for 'Pound The Alarm' below: