Swift will debut a song from her new studio record Red during the September 6 awards ceremony.
Miley Cyrus also leads a new group of MTV Video Music Awards presenters. She will be joined by Olympic gold medal gymnasts Gabby Douglas, Jordyn Wieber, Aly Raisman, McKayla Maroney and Kyla Ross.
Wiz Khalifa and rapper Mac Miller will be present to hand out the moonmen trophies as well.
Pink, Green Day, One Direction and Alicia Keys have previously been announced as performers for the gala event.
Rihanna and Drake lead this year's Video Music Awards nominees, while Justin Bieber, Nicki Minaj, Kanye West and Gotye have also earned multiple nods.
Kevin Hart hosts the 2012 MTV Video Music Awards, airing live from the Staples Centre in Los Angeles on Thursday, September 6 at 8/7c.
Watch Taylor Swift's 'Mean' music video below: