The DJ confirmed that the title of his new single will be 'Sweet Nothing' and will feature Florence Welch.
"Shooting the video for 'Sweet Nothing' with @flo_tweet right now! Exciting!!" Harris tweeted.
"Wow… watching @flo_tweet perform in this video today was a real treat… incredible… can't wait for you to see/hear our song!"
Posting a picture of herself on set, Welch added: "Arrive at mysterious working mans club for start of 'sweet nothing 'vid, glad the queen is here to welcome me. No prince Harry though :(.
"So far style references are ELVIS, Lyillia 4 Eva and… vintage tranny. But there is also a lot of Agent Provocateur bondage style underwear here… and a stripper pole."
Harris recently confirmed that his new album 18 Months will be released at the end of October and also feature collaborations with Rihanna and Kelis.
Listen to the Calvin Harris remix of Florence + the Machine's 'Spectrum' below: