The 'Survival' band are the latest act to sign up for the month-long event at the Roundhouse in London, which takes place throughout September.
They will headline the venue on September 30, the day before their latest album The 2nd Law is released.
Noel Gallagher, Olly Murs, One Direction and Ellie Goulding are among the long list of artists who will perform next month.
Delilah, Conor Maynard, Bat for Lashes, Calvin Harris and OneRepublic will appear as some of the support acts during the festival.
Listen to Muse's 'Madness' below:
September 27 is currently the only date which has yet to be filled.
Tickets for each gig are given away for free through the iTunes Festival website. Applicants are expected to be told whether they have won tickets or not soon.
Muse recently said that The 2nd Law is the "weirdest" album that they have ever made.
The iTunes Festival line-up is as follows:
Usher, Miguel (September 1)
Ed Sheeran, Charli XCX (2)
Olly Murs, The Milk (3)
Plan B, Delilah, Ryan Keen (4)
Emeli Sande, Bastille, Gabrielle Aplin (5)
JLS, Conor Maynard (6)
Elbow, Bat For Lashes (7)
Jack White, Band Of Horses (8)
Deadmau5, Foreign Beggars (9)
Norah Jones, Beth Orton (10)
The Killers, Jake Bugg (11)
Noel Gallagher's High Flying Birds, The Soundtrack Of Our Lives (12)
Pink, Walk The Moon (13)
Labrinth, Josh Kumra (14)
David Guetta, Calvin Harris (15)
Rebecca Ferguson (16)
Example, DJ Fresh, Hadouken! (17)
Andrea Bocelli, Laura Wright, CARisMA (18)
Matchbox Twenty, OneRepublic (19)
One Direction, Angel (20)
Jessie J, Lonsdale Boys Club (21)
Biffy Clyro, Frightened Rabbit (22)
Robert Glasper, Jose James (23)
Mumford & Sons, Willy Mason (24)
Lana Del Rey (25)
Ellie Goulding, Haim (26)
Alicia Keys (28)
Hot Chip (29)