The band explained that they weren't afraid to be more operatic on their new record The 2nd Law, which is out on October 1.
''We don't care if people don't necessarily take songs like that 100% seriously," frontman Matt Bellamy is quoted by Contact Music as saying.
''We're not afraid of our eccentricities, we're not afraid of going into almost Monty Python rock. But it's like opera. If you put a piece of opera on, it's ridiculous unless you've listened to the whole thing and just go there with it.
''It was so operatic. So completely different to how I heard it in my head. But that's what it's all been about: writing stuff to challenge us to sound different from what we think we sound like.''
Muse recently unveiled their new single 'Madness', which is available to download now.
The band will play a headline set at London's Roundhouse on September 30 as part of the iTunes Festival 2012.
Listen to Muse's new single 'Madness' below: